The Therapeutic Efficacy of Microneedling Combined with Topical Tacrolimus versus Microneedling Alone in Treatment of Stable Vitiligo. A Comparative Study.

Main Article Content

Huda Nahi Tehewel
Shihab Abdlrahman Shihab
Ahmed Abdul-Aziz Ahmed
Muqdad A. Dahash
Dalya M. Fateh
Wisam S. Najim

Abstract

Background: Vitiligo is an acquired depigmentary disorder of multifactorial etiology. Several treatment modalities have been attempted with partial success, but the recent focus on surgical treatment like micro-needling.
Objective: To compare the safety and ability of micro-needling alone in the induction of pigmentation in stable vitiligo versus combined tacrolimus treatment and micro-needling.
Patients and methods: Twenty three patients with stable vitiligo were recruited from the Department of Dermatology and Venereology of Salah Aldeen General Hospital. The patients then subjected to micro-needling of the two vitiliginous patches after that application of topical tacrolimus to the left patch. This procedure was repeated every two weeks for a maximum of 5 months ( 10 sessions).
Results: Microneedling with topical tacrolimus showed better but non-significant response than micro-needling alone ( p = 0.519). Moderate improvement occurred in 13% of patches treated with micro-needling alone, while only 9% show moderate improvement in combined treatment. Although 9% show good improvement in combined treatment.
Conclusion: Micro-needling induces pigmentation in vitiligo patients, and the addition of topical tacrolimus induces a better response.However, no statistically significant response was observed in any group.

Article Details

How to Cite
1.
Tehewel H, Shihab S, Ahmed A, Dahash M, Fateh D, Najim W. The Therapeutic Efficacy of Microneedling Combined with Topical Tacrolimus versus Microneedling Alone in Treatment of Stable Vitiligo. A Comparative Study. IJPQA [Internet]. 25Jan.2013 [cited 2Jul.2020];11(01):74-2. Available from: https://www.ijpqa.com/index.php/IJPQA/article/view/970
Section
Research Article