Synthesis and Characterization of Some New Heterocyclic Derivatives and Studying of their Biological Activity (anti-bacteriaa)

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Zahraa Falah Khudair
Shaimaa Adana Bhagat

Abstract

Introduction: In this work synthesis, many kinds of heterocyclic derivatives by many steps, the first we preparation 1-(4-((1H-imidazol_2-yl-) diazenyl) phenyl) ethan-1_one.(1) by coupling of diazonium salt of p-amino acetophenone with imidazole in alkaline alcoholic media, the second step include react (1) with 2_amino_6_methylpyrimidin _4_ol in acid medium to get Schiff base derivatives(2)the last step include react(2) with (sodium azide, thioglycolic acid, glycine, alanine, Tryptophan, (2 aminobenzoic acid), (2-mercaptobenzoic acid) to give (tetrazole(3) thiazolidine(4), imidazolidine(5-7), Thiazinie(8), Quinazoline (9) derivatives respectively all these derivatives Characterization by FTIR, 1HNMR, 13C-NMR, After that we studied the biological activity for all derivatives for all derivatives studied the anticancer for (2).

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How to Cite
1.
Khudair Z, Bhagat S. Synthesis and Characterization of Some New Heterocyclic Derivatives and Studying of their Biological Activity (anti-bacteriaa). IJPQA [Internet]. 25Jan.2013 [cited 2Jul.2020];11(01):31-6. Available from: https://www.ijpqa.com/index.php/IJPQA/article/view/960
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Research Article