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This study was carried out to investigate the immunomodulatory effects of the Boric acid on the immune responses of mice that vaccinated by Proteus Vulgaris antigens. The study was included six groups; the first group (I) was treated with distilled water. The II group was mice treated with Proteus Vulgaris antigens only, (III) group: injected subcutaneously with a dose of (600 ug/Kg), IV group was injected subcutaneously with a dose of (400 ug /Kg) boric acid. The V and VI groups were treated with p. Vulgaris and boric acid. All these groups were carried out at day 1; then, the mice were killed on day 8 to estimate the parameter. The phagocytic activity index was estimated by Eliza reader. While on day I4 the lymphocyte transformation was estimated by MTT index and by Eliza reader. In this regard, all groups of mice showed different significant increases (P≤ 0.05) in the NBT index as compared with group I, the control group, which was injected with distilled water and group 5 and 6 showed increasing significantly compared with group II. III. IV. On the other side of the study, the results of the lymphocyte transformation index in mice of all groups were showed different significant as compared to group I. The best treatment efficiency was recorded in-group V, VI compared with treated groups II. III. IV). The results demonstrated a clear immunomodulatory effect of boric acid (enhancement of nonspecific immunity, and adaptive immunity) of the treated mice immunized with P. Vulgaris.
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