The Utilization of Standard Addition Method for the Determination of Ibuprofen in Liquid Dosage Form

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Rajwan A Alazawy
Awatef A Ebrahim Al Ani
Sura L Alkhafaji

Abstract

Objective: The use of the standard addition method is common in drug analysis protocols. This study aims to quantify the ibuprofen within a pharmaceutical liquid preparation with the aid of a standard addition method relying on robust studies employing the UV-Visible spectrophotometric techniques. Methods: The oral pediatric syrup liquid dosage form of ibuprofen (Brufen®), wear diluted and inoculated with predetermined spikes of the ibuprofen standards. Consequently, these prepared samples were analyzed, employing UV-Vis techniques. Results: The absorbance versus concentration standard curve was plotted for Brufen®. This curve shows good linearity. The regression coefficient of 0.9942. The Limit of detection (LOD = 3SD) and Limit of quantification (LOQ = 10SD) were found to be 0.00755 and 0.02517, respectively. The percent amount was found to be 101.533% of ibuprofen content. Conclusion: In conclusion, the researchers find the standard addition method as a reliable method to acquire rapid, economy, and validated the method for the quantitation of ibuprofen oral pediatric syrup dosage forms, thus, can be utilized in routine laboratory drug-analysis works.

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Research Article