Molecular Study of AHR Gene Polymorphisms among Iraqi Women Staff Working in Radiotherapy Units

Wathiq A Al-Draghi, Mushtaq T Hassan

Abstract


Radiation may impact the DNA directly, causing its ionization or cause an indirect action in this case, the radiation interacts with non-critical target atoms or molecules, usually water which results in the production of free radicals. These free radicals can then attack critical targets such as the DNA. Radiation is considered carcinogenic. in this study were the evaluation the Ahr gene polymorphisms among Iraqi staff working in radiotherapy units. This case control study include two groups : fifteen healthy women as control group and fifteen radiologist. Ahr polymorphism has been done at two loci G1721A and G1768A using alleles specific PCR. Nucleotide polymorphism variants and different genotypes of Ahr gene have important roles in the development of cancer. This was mainly seen in Ahr polymorphism in GG and GT variants of G1721A, GG and GT variants of G1768A. High risk of radiation damage was noticed in the GG1768 genotype where (OR=3.25(0.5185-20.3704),p=0.2082)and (RR=2.49) also GT1721 genotype It can reflect radiation risks where (OR=1.62(0.2303-11.464)and (RR=1.5). All these results imply that SNPs studies must be conducted on cancer patients and radiation staffs as routine investigation to watch for and prevent DNA damage as much as possible.

Keywords


Ahr gene, polymorphism, Iraqi women, radiotherapy units.

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DOI: http://dx.doi.org/10.25258/ijpqa.10.2.12

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